Tubercular Mastitis Masquerading As Carcinoma: A Case Report
Abstract
Tubercular mastitis is an extremely rare disease even in tuberculosis-endemic countries like India. A 52-year-old multiparous, postmenopausal female presented with a progressively increasing painless lump in the right breast. A mammogram was requested which pointed towards a malignant lump. The lump was subjected to fine needle aspiration cytology which revealed epitheloid cell granulomas, Langhans giant cells and lymphohistiocytic aggregates. Ziehl-Neelsen staining of the aspirate was positive for acid fast bacilli. The patient was put on antituberculous treatment for a period of nine months. The lump gradually disappeared and our patient is doing well at 6 months of follow-up.
Introduction
Tubercular mastitis is an extremely rare disease even in tuberculosis-endemic countries like India. Its incidence has been variously described as between 0.1 and 3%1. The first case of tubercular mastitis was described by Sir Astley Cooper in 18292. Diagnosis is difficult because of nonspecific clinical and radiological findings. It should particularly be kept as a differential diagnosis in a young lactating, multiparous female who presents with a hard lump of the breast especially in the setting of a third world country.
Case report
A 52-year-old multiparous, postmenopausal female presented with a progressively increasing painless lump in the right breast. There were no associated constitutional symptoms. On examination, it was a 3x2cm hard, non-tender, mobile lump in the upper outer quadrant. Nipple, areola and overlying skin were normal. There was no axillary or cervical lymphadenopathy. The opposite breast was normal. Chest and abdominal investigations were normal. Chest radiograph, basic hematological and biochemical investigations were within normal limits.
A mammogram was requested which pointed towards a malignant lump (Fig – I). The lump was subjected to fine needle aspiration cytology (FNAC) which revealed epitheloid cell granulomas, Langhans giant cells and lymphohistiocytic aggregates. Ziehl-Neelsen staining of the aspirate was positive for acid fast bacilli (AFB). The patient was put on antituberculous treatment (ATT) for a period of nine months (HRZE x 2 months + HR x 7 months). The lump gradually disappeared and our patient is doing well at 6 months of follow-up.
Figure 1: Mammogram showing a lesion in the upper outer quadrant
Discussion
Tubercular mastitis is an extremely rare disease of the younger age group. Occasionally, an older patient may present with a lump that masquerades malignancy. The rarity of this disease has been attributed to the relative resistance of the breast tissue towards colonisation and division of mycobacteria3. The risk factors considered to be associated with tubercular mastitis are multiparity, lactation, trauma, past history of suppurative mastitis and AIDS4,5. It has been cassified into three distinct pathological types – nodular, diffuse and sclerosing6. The nodular variety is the most common and mimicks fibroadenoma or carcinoma, the diffuse variety presents with caseation and sinus formation, whereas the sclerosing variety shows extensive fibrosis with hard lumps resembling carcinoma.
The portal of entry of tubercular bacteria can be:
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Primary
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by direct inoculation of bacilli through abrasions over the nipple which is very rare or,
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Secondary
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by lymphatic (most common route)
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or hematogenous as in miliary tuberculosis,
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or contiguous spread from chest wall structures.
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The clinical features of tubercular mastitis are sometimes indistinguishable from breast cancer and associated constitutional symptoms may also be absent in the majority. Mammography and ultrasonography do not clinch the diagnosis as features are largely nonspecific. In most cases, FNAC settles the diagnosis by showing characteristic epitheloid cell granulomas, Langhans giant cells and lymphohistiocytic aggregates which is sufficient for diagnosis3,8. Zhiel-Neelsen staining for AFB is positive in only 25% of cases and hence is not mandatory for diagnosis3,8.
Treatment options include a 9 month regimen of ATT starting with 4 drugs (HRZE x 2 months) and then going on with two drugs (HR x 7 months) in the maintenance phase with or without lumpectomy.
A lack of response to ATT or a diffusely deformed breast with ulceration or sinuses may require simple mastectomy9. Our patient responded well to medical management alone.
In conclusion, we suggest that tubercular mastitis is a rare but important differential diagnosis for a clinically malignant breast lump, especially in a young patient in third world countries.
Correspondence to
Dr. Rajesh Godara 58/9J, Medical Enclave Rohtak Haryana (India) - 124001. Email : drrajeshgodara@yahoo.co.uk
