The Internet Journal of Radiology™ ISSN: 1528-8404

Share with others |

FDG PET Imaging Of Hypothalamic Langerhans Cell Histiocytosis

Read printer friendly

Subscribe in a reader

Share with others

Eugene C Lin M.D.
Assistant Professor
Radiology
Nuclear Medicine
University of Colorado

Citation: E. C. Lin : FDG PET Imaging Of Hypothalamic Langerhans Cell Histiocytosis . The Internet Journal of Radiology. 2001 Volume 2 Number 1

Keywords: Radiology | medicine | Langerhans Cell Histiocytosis | F-18 Fluorodeoxyglucose | Positron Emission Tomography

Case Report

Abstract

A case of intense FDG uptake in the hypothalamus secondary to Langerhans cell histiocytosis involving the hypothalamus is presented.

Case Report

A 24-year woman with Langerhans cell histiocytosis (LCH) had a positron emission tomography (PET) scan (Fig. 1) demonstrating intense F18-fluorodeoxyglucose (FDG) uptake in the hypothalamus. A contrast-enhancing hypothalamic mass was demonstrated by magnetic resonance imaging (MRI) (Fig. 2), corresponding exactly to the area of intense FDG uptake. This mass had been stable for two years and was thought to represent LCH involving the hypothalamus. LCH can show significant gadolinium enhancement on MRI (¹, ²) and the hypothalamus is the most common area of brain involvement in LCH (³). The appearance of LCH on FDG PET has not been previously described in any area of the body. This case illustrates that LCH involving the brain can demonstrate intense FDG uptake, potentially mimicking high-grade gliomas. Correlation with patient history and knowledge of the pattern of LCH involvement in the brain is necessary to avoid misdiagnosis.

Figure 1: Coronal image from a PET scan performed with 11.0 mCi (407 MBq) of FDG demonstrates intense FDG uptake in the hypothalamus (arrow).

Figure 2: Coronal T1-weighted (TR 537, TE 20) gadolinium-enhanced MRI demonstrates focal hypothalamic enhancement (arrow), corresponding to the area of increased FDG uptake.

References

1. George JC; Edwards MK, Smith RR, Provisor AJ: MR of intracranial Langerhans cell histiocytosis. J Comput Assist Tomogr 18 (2):295, 1994. (s)

2. Langerhans cell histiocytosis involving the corpus callosum and cerebellum: gadolinium-enhanced MRI. Neuroradiology 37 (4):289, 1995. (s)

3. dAvella D; Giusa M; Blandino A, et al: Microsurgical excision of a primary isolated hypothalamic eosinophilic granuloma: Case report. J Neurosurg 87(5): 768, 1997. (s)

This article was last modified on Fri, 13 Feb 09 14:10:21 -0600

This page was generated on Sun, 21 Mar 10 18:18:39 -0500, and may be cached.

The Internet Journal of Radiology™ ISSN: 1528-8404

FDG PET Imaging Of Hypothalamic Langerhans Cell Histiocytosis

Related Articles

Table of Contents

Abstract

Case Report

References


	The Internet Journal of Radiology™ ISSN: 1528-8404 \| Home \| Editors \| Current Issue \| Archives \| Instructions for Authors \| Disclaimer \| Share with others \| FDG PET Imaging Of Hypothalamic Langerhans Cell Histiocytosis Read printer friendly Subscribe in a reader Share with others Related Articles Have The ASA Guidelines For Sedation And Analgesia Affected The Practice Of Non Anesthesiologists? Pulmonary Artery Bronchial Fistula After Sleeve Lobectomy, A Case Report: A Fatal Complication Of Sleeve Lobectomy Anesthesia for Interventional Neuroradiology: Part III: Anesthetic goals and techniques "The Most Beautiful Painting" Transcranial Doppler: An Overview of its Clinical Applications Eugene C Lin M.D. Assistant Professor Radiology Nuclear Medicine University of Colorado Citation: E. C. Lin : FDG PET Imaging Of Hypothalamic Langerhans Cell Histiocytosis . The Internet Journal of Radiology. 2001 Volume 2 Number 1 Keywords: Radiology \| medicine \| Langerhans Cell Histiocytosis \| F-18 Fluorodeoxyglucose \| Positron Emission Tomography Table of Contents Case Report Abstract A case of intense FDG uptake in the hypothalamus secondary to Langerhans cell histiocytosis involving the hypothalamus is presented. Case Report A 24-year woman with Langerhans cell histiocytosis (LCH) had a positron emission tomography (PET) scan (Fig. 1) demonstrating intense F18-fluorodeoxyglucose (FDG) uptake in the hypothalamus. A contrast-enhancing hypothalamic mass was demonstrated by magnetic resonance imaging (MRI) (Fig. 2), corresponding exactly to the area of intense FDG uptake. This mass had been stable for two years and was thought to represent LCH involving the hypothalamus. LCH can show significant gadolinium enhancement on MRI (¹, ²) and the hypothalamus is the most common area of brain involvement in LCH (³). The appearance of LCH on FDG PET has not been previously described in any area of the body. This case illustrates that LCH involving the brain can demonstrate intense FDG uptake, potentially mimicking high-grade gliomas. Correlation with patient history and knowledge of the pattern of LCH involvement in the brain is necessary to avoid misdiagnosis. Figure 1: Coronal image from a PET scan performed with 11.0 mCi (407 MBq) of FDG demonstrates intense FDG uptake in the hypothalamus (arrow). Figure 2: Coronal T1-weighted (TR 537, TE 20) gadolinium-enhanced MRI demonstrates focal hypothalamic enhancement (arrow), corresponding to the area of increased FDG uptake. References 1. George JC; Edwards MK, Smith RR, Provisor AJ: MR of intracranial Langerhans cell histiocytosis. J Comput Assist Tomogr 18 (2):295, 1994. (s) 2. Langerhans cell histiocytosis involving the corpus callosum and cerebellum: gadolinium-enhanced MRI. Neuroradiology 37 (4):289, 1995. (s) 3. dAvella D; Giusa M; Blandino A, et al: Microsurgical excision of a primary isolated hypothalamic eosinophilic granuloma: Case report. J Neurosurg 87(5): 768, 1997. (s) This article was last modified on Fri, 13 Feb 09 14:10:21 -0600 This page was generated on Sun, 21 Mar 10 18:18:39 -0500, and may be cached.
Home \| Journals \| Sponsors \| Books \| PubMed \| Editorial Help \| Privacy Policy \| Disclaimer \| Job Opportunities \| Contact Copyright Internet Scientific Publications, LLC., 1996 to 2010.